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PGE: prostaglandin E An increasing number of studies demonstrate that maternal- or early-life stress-induced dysregulation of the stress system involving increased or decreased concentrations of stress hormones as well as an alteration in the expression of their receptors, might promote several key processes involved in tumour initiation and progression

doi: 10.1038/onc.2015.381
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Recently, several groups have reported the role of ER stress in the development of leptin resistance and obesity [176, 184, 185]

MetS and diabetes The worldwide prevalence of MetS and type 2 diabetes is increasing
