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Single-cell transcriptomic profiling of CTCs collected during resting phases reveals elevated mitotic activity, providing a mechanistic basis for time-dependent metastatic potential and underscoring the importance of chronobiology in cancer diagnosis and therapy (176)

Its prevalence rose 50.4% worldwide between 1990 and 2019 (25.26%38.00%), with the highest rates found in South Asia (33.83%), the Middle East/North Africa (36.53%), and Latin America (44.37%), while Western Europe had the lowest frequency (25.10%) (Younossi et al., 2023)

This suggests that differences in muscle development could affect susceptibility to the effects of MuSK antibodies and might partially explain the clinical pattern of weakness in MuSK-MG