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Increased serum and brain concentrations of lactate, pyruvate, lactate/pyruvate ratio, alanine, and creatine kinase, at 31%, 14%, 28%, 8%, 47%, 35%, 46%, and 7%, respectively, and low carnitine were described in 90% of children with ASD in the review of Rossignol and Frye [38]

Toxicity caused by valproic acid seems to be linked with L-carnitine deficiency

Any performance-related benefits tend to be modest and highly individualised

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