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Statistical analysis All statistical analyses in this study were performed using GraphPad Prism software (version 9.0.0)

The metabolic support process develops progressively over weeks to months, with optimal results requiring consistent administration alongside proper nutrition and exercise

Jaunmuktane and Brandner, 2020)

3 Metabolic and hormonal interventions 3.1 Tirzepatide: improving age-related metabolic parameters Metabolic dysfunction represents a central feature of biological aging, characterized by progressive insulin resistance, dysregulated glucose homeostasis, accumulation of visceral adiposity, and increased risk of type 2 diabetes and cardiovascular disease ( Beyond glycemic and weight effects, tirzepatide may influence aging through multiple mechanisms