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p53 Protein-mediated regulation of phosphoglycerate dehydrogenase (PHGDH) is crucial for the apoptotic response upon serine starvation
In Porphyromonas gingivalisinduced periodontitis, HIF-1 exacerbates inflammasome activation in macrophages (Okano et al., 2025)
The six-carbon sugars can be recycled into the pathway in the form of G6P, generating more NADPH
Both the thioredoxin (Trx) and GSH-dependent glutaredoxin (Grx) antioxidant systems have been found to reduce methionine sulfoxide reductases in vitro and/or in vivo (see Figure 2 ) (28)
