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In parallel, dysfunction of cytoplasmic Pattern Recognition Receptors (PRRs) (e.g., retinoic acid-inducible gene I) impairs downstream type I interferon (IFN-I) signalling, resulting in diminished phagocytic capacity and blunted IFN-I responses [48]

13 Vitamin D deficiency: Vitamin D influences the expression of structural proteins (claudins and occludins) integral to gut barrier tight junctions, making adequate levels essential for intestinal integrity

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The hepatic first-pass effect can be avoided to a great extent by use of sublingual tablets and transdermal preparations and to a lesser extent by use of rectal suppositories