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As long as the trend line moves in the right direction, the protocol is working

*Correspondence: Jiang-Hua Li, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Contradictions and Precautions Tirzepatide is contraindicated in patients with: A personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

Gastrointestinal Symptoms : nausea, vomiting, diarrhea, constipation, abdominal pain, reflux, heartburn, and impaired motility Secretomotor Symptoms : difficulty sweating, tearing, and other fluid production (dry eyes, dry mouth, difficulty swallowing, dry skin)