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We suggest that reduced GPx1 in monocytes recruited to the gut and intestinal macrophages renders these cells vulnerable to reactive oxygen species-evoked ferroptosis cell death and that unraveling the participation of this pathway in Crohns disease may reveal novel therapeutic approaches to this chronic condition

Multiple Chemical Sensitivity (MCS) And Detox Concerns Multiple chemical sensitivity is linked with impaired detoxification and higher oxidative stress, including lower glutathione and altered glutathione-related enzymes

T H 17 cell differentiation was regulated mainly via Got1-dependent increased transamination leading to elevated 2-hydroxyglutarate (2-HG) level in differentiating T H 17 cells
