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Description
Instead of targeting TAAs, UniCARs are engineered to recognize the human peptide sequence E5B9, also known as the UniCAR epitope, which is a fragment of the human nuclear autoantigen La/SS-B and absent in living cells (Jureczek et al., 2019)

The proportion of participants with resistant hypertension at baseline (n=167) that reached BP targets at week 68 was 42.0% and 29.3% for CagriSema and placebo, respectively (odds ratio, 1.7 [95% CI, 0.74.4])

Perhaps subcutaneous injections might suit hef better

In a phase 2 trial published in The New England Journal of Medicine , retatrutide produced substantial weight loss in adults with obesity or overweight over 48 weeks, with the highest-dose groups achieving reductions that reached up to 24.2%
