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Semaglutide & Tirzepatide: these unique peptides have recently become popular for treating both diabetes and obesity, providing rapid and substantial weight loss by activating the GLP-1R signaling pathway to stimulate glucose-dependent insulin secretion via activity at the GIP receptor (GIPR) or the GLP-1R, as well as augmenting insulin secretion, inhibiting glucagon release and hepatic gluconeogenesis, improving insulin resistance, reducing adverse cardiovascular events like heart attack and stroke, and suppressing gastric emptying and appetite

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