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New directions in therapeutic angiogenesis and arteriogenesis in peripheral arterial disease

Recent evidence, however, highlights that beyond detoxification, SQOR integrates sulfide oxidation with ubiquinone redox cycling, modulates mitochondrial respiratory capacity, and generates hydropersulfides and thiosulfate that act as radical-trapping antioxidants (Lee et al., 2025)

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Therefore, SQOR is not only a key molecule for understanding the pathophysiological mechanisms of these complex diseases, but is also increasingly being recognized as a promising therapeutic target and diagnostic biomarker (Lee et al., 2024