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Plasma thiols and disulfides are not in equilibrium, but appear to be in a steady state maintained in part by transport of these compounds between tissues during the interorgan phase of their metabolism

[45] Beyond genetics, epigenetic abnormality related to DNA methylation, histone acetylation, or microRNA expression probably has a key role in the pathogenesis of autoimmune diseases, including Sjgren's disease

While methylation plays a role in many central processes, its most important functions are: Controlling DNA/epigenetics Methylation is utilised in the body to switch genes off and on

By the middle of the twentieth century, enzymatic systems able to catalyse NADPH-dependent reduction of glutathione had also been detected in plant tissues (Conn and Vennesland 1951