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Finally, we evaluated the effects of colchicine on HBV replication and HBc-mediated HCC metastasis in vitro and in vivo

For example, his-tags bind to nickel agarose beads, GST-tags bind to glutathione agarose, and biotinylated molecules or strep-tags bind to streptavidin beads

By integrating effect directions and robustness across models, we identified most potential drug candidates, evaluated the efficacy of novel strategies, and recognized critical translational gaps

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