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Many candidate compounds (such as curcumin) have poor oral bioavailability, rapid metabolism, formulation-dependent exposure, and uncertain CNS penetration, while plasma pharmacokinetics may not accurately represent drug levels within compartmentalized CNS lesions, especially in progressive disease (Liu et al., 2016

Research institutions should review their receiving procedures to ensure prompt identification of any quality issues

For patients with neurological involvement, maintenance injections are typically given every 2 months

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