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& Barbara, S

A diagnosis of hEDS is made clinically using the 2017 diagnostic criteria

By contrast, priming refers to the transformation of PMNs following exposure to a ligand that does not itself induce superoxide production, but does render the PMNs more amenable to robust activation of NADPH oxidase upon binding to a second ligand (El-Benna et al., 2008, 2016)

Our goal is to administer shots so that they cause little to no pain
