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What makes 5-Amino-1MQ interesting is its ability to block NNMT, an enzyme that rises in obesity and aging

It is thought that the secondary pathway by which AOD9604 causes fat loss, the pathway that is independent of beta-3-adrenergic receptor activation, may play a role in improving metabolic metrics even while it boosts fat loss- AOD9604 exhibits minimal side effects, high oral and excellent subcutaneous bioavailability in mice

An NIH-indexed review of obesity pharmacotherapy confirmed the termination rationale: the drug failed to demonstrate sufficiently meaningful weight loss to be commercially viable
