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Abstract Lung cancer remains a major global health challenge and one of the leading causes of cancer-related deaths worldwide

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Naturally occurring R-LA in foods covalently bound to lysine in proteins (lipoyllysine), while LA in supplements is free (Singh and Jialal, 2008)

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below the mean were promptly resynthesized, retested for ENL degradation in a newly optimized MV4;11 HiBiTENL cell line and counterscreened against MV4;11 cells expressing bromodomain-containing protein 4 (BRD4)HiBiT to remove false positives, as TM-7 itself does not bind BRD4 (Fig

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It has been shown to inhibit cell proliferation in various cancer cells, such as MCF-7, LnCaP, and MDA-MB-231 in vitro (Garibsingh et al., 2020)

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