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Description
Estrogens also signal through membrane-bound receptors (e.g., GPER1 and palmitoylated-ER variants) to initiate non-genomic signaling, and these pathways often intersect and cross-regulate each other (145148)

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Available from: 10.1016/j.jcrs.2016.08.013 [DOI] [PubMed] [Google Scholar] Google Patents

This is probably due to reduced synthesis and increased irreversible utilization by non-glycemic mechanisms
