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Moreover, the data based on epidemiological analysis, clearly suggested that liver cirrhosis had inverse relationship with coffee consumption

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176 (3) the AOL domain, which is an amine oxidase-like domain locating at the C-terminal of LSD1 and is divided into two regions by the Tower domain, one is used for substrate binding and recognition, and the other is defined as the binding site of non-covalent FAD (Fig

Within HSCs, curcumin enhances PPAR functionality while mitigating oxidative stress through Ob-R dephosphorylation, subsequently suppressing Ob-R transcription and blocking leptin-mediated signaling, thereby abolishing leptins pro-activation effects on HSCs (Tang et al., 2009)