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J Nutr Biochem 85:108459

Strain JJ, McSorley EM, van Wijngaarden E, Kobrosly RW, Bonham MP, Mulhern MS, McAfee AJ, Davidson PW, Shamlaye CF, Henderson J, Watson GE, Thurston SW, Wallace JM, Ueland PM, Myers GJ The British journal of nutrition

Use of Proton Pump Inhibitor may decrease bone strength and increase the incidence of insufficiency fractures by inhibiting proton pumps in osteoclasts and decreasing bone turnover, impairing calcium absorption, and altering homocysteine levels through impairment of folate and vitamin B12 absorption

TECs were able to secrete exosomes enriched with miR-21-5p that could induce autophagy in alveolar macrophages (AMs) by activating the PI3K/Akt pathway through targeting the PIK3CD gene of the AMs, thereby inhibiting ROS overproduction