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Beyond presynaptic deficits, chronic dopamine depletion leads to postsynaptic adaptations, including downregulation of D2/3 receptors and inflammationmediated desensitization of downstream signaling pathways [201]

doi: 10.3389/fphar.2024.1503064 85

Apart from the well-documented GPx-like catalytic activity, ebselen is also reported for directly scavenging the biologically relevant ROS (like peroxyl and singlet oxygen) and reactive nitrogen species (peroxynitrite) with rate constants comparable to standard antioxidants

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