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Pharmacokinetic profiles for the compound place its plasma half-life in the neighborhood of 45 minutes after parenteral administration in animal models, which informs typical dosing intervals in published experiments
Yet another compound, Honokiol (HKL), has been shown to protect against doxorubicin-induced cardiotoxicity by activating SIRT3, which helps reduce ROS production, prevent mitochondrial fragmentation, and promote mitochondrial fusion 187
