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They include, but are not limited to: excess endurance exercising excess weight lifting lack of key antioxidant nutrients like Vitamin C, Vitamin E, Selenium, Magnesium and other minerals excess radiation or sunlight smoking (huge cause of oxidative stress) excessive drinking or drug use over-exposure to toxins in our air, water and foods like pesticides, chemicals, heavy metals and more prescription medications processed foods with all their artificial dyes, additives or flavorings excess physical trauma Graves disease aka hyperthyroidism excess copper levels from the MTHFR defect Your thyroid condition and Oxidative Stress In addition to all the above, there are a vast amount of documentation about the strong relationship between hypothyroidism and Oxidative Stress