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Similarly, chronic treatment with 3-AR agonists have been shown to decrease adiposity and improve insulin resistance in obese rodents (224, 225)

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Deficiency Risks and Who Is Most Affected Certain groups are at higher risk of deficiency, including: Vegetarians and vegans Adults over 50 with reduced stomach acid Patients with gut disorders such as Crohns or celiac disease Those taking long-term acid-reducing medications Symptoms of deficiency can include fatigue, pale skin, memory loss, depression, numbness, or tingling sensations