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In autistic individuals, dysregulation of glutathione-related regulation of glutamate receptors, such as the N-methyl-D-aspartate receptor, can contribute to glutamate excitotoxicity and neuronal dysfunction

The double-blind multicenter phase 3 trials STEP 1, 3, 4, 5 were conducted in adults (mean age 46.247.3 years), mostly females, with obesity or overweight with 1 weight-related complication (mean BMI 37.838.4 kg/m 2 ) and aimed to demonstrate the superiority of semaglutide 2.4 mg over placebo in BW lowering at 68 or 104 24 weeks as an adjunct to diet and physical activity 23

If the bottle is left unopened, the shelf life is 2 years

PubMed Link Zamani B, et al