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Moreover, we found that TGFb ligand treatment led to an increase in SNCA expression in our PD cell model, and aSyn-overexpression led to an up-regulation of TGFB1 , TGFB2 , SMAD2 , and SMAD3 in LUHMES cells

As single-cell and multi-omics technologies continue to mature, researchers will increasingly be able to profile DNA methylation, histone modifications, chromatin accessibility, and gene expression within the same cell, thereby generating a more accurate picture of epigenetic changes associated with depression and addiction 186,187

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The methionine overload would tend to decrease basal hyperhomocysteinemia rather than cause a further increase in basal hyperhomocysteinemia in patients bearing remethylation defects such as folate deficiency (associated or not with the C677T mutation of the MTHFR gene) (Durand et al, 1997a