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While this rapid evolution toward multi-agonist strategies and oral formulations promises enhanced efficacy, tolerability, and adherence, generating robust long-term safety and efficacy evidence remains imperative

Especially, because GCs are well-known inhibitors of COX-2 and NF-B expression [189]

Given that the therapeutic effectiveness of type II PSs is highly dependent on the surrounding oxygen concentration, Wang et al

The study concluded that the aforementioned ferroptosis-related genes exhibit excellent diagnostic ability for SIC and that some of these genes are associated with the prognosis of SIC and have potential as therapeutic drugs