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Critical Reviews in Clinical Laboratory Sciences

In humans, cyanocobalamin must undergo intracellular enzymatic conversion to the active coenzyme formsmethylcobalamin and adenosylcobalaminwhich, depending on the pH environment, can interconvert with hydroxocobalamin (Obeid et al., 2015)

Testing MTHFR and other relevant genetic markers can identify these individuals, though routine genetic testing for b12 supplementation decisions remains controversial

Lung Cancer In 2017, a study found that men taking B12 supplements appeared to have an increase in lung cancer risk
