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Because vitamin B12 helps the body produce brain chemicals that can affect mood and cognitive functions, a deficiency may lead to anxiety or depression
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Also since most of serine inhibiting phosphorylation occurs in IRS-1, it renders IGF-1R a rescue pathway to reinstitute insulin sensitivity
"Ml muscarinic agonists can modulate some of the hallmarks in Alzheimer's disease: implications in future therapy." J Mol Neurosci 20(3): 349- 56
