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Ethical approval All procedures followed were in accordance with the ethical standards of human experimentation and the Declaration of Helsinki

Considering the critical importance of CBF delivery in maintaining neuronal health and function, these findings alone warrant further interventional investigations on how long-term RT affects cerebrovascular function in older adults across the cognitive and neurodegenerative spectrum

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GPX5 is described in the epididymis as a secreted protein that contains cysteine (Cys) in the active center instead of Sec, GPX5 is the first discovered Cys-based superfamily member, also known as epididymal GPX (EGPX), which has now been shown to play a role in protecting mouse sperm from hydrogen peroxide toxicity (Zhang et al., 2008