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doi: 10.1007/s10067-014-2517-2 PMCID: PMC3962576 The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain Jarred Younger, Luke Parkitny, and David McLain Curr Rheumatol Rev
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Excretion Pathways Limited data on combined excretion indicates[21]: Primarily renal elimination of peptide fragments from all components Hepatic metabolism contributes to overall clearance Copper recycling through normal physiological pathways (GHK-Cu component) No evidence of accumulation in chronic dosing studies of individual components BPC-157 detectable in urine for up to 4 days

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