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Description
In addition, poor solubility, limited BBB penetration, and low oral bioavailability-coupled with significant inter-individual variability in absorption and metabolism-pose substantial barriers to dose standardization and reproducibility
This aspect is crucial for long-term management strategies in schizophrenia, where treatments often continue for 1 to 5 years after the condition stabilizes (232)
PMID: 2425690
Stuttgart: Wissenschaftliche Verlagsgesellschaft Stuttgart, 2008
