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Vehicle control C57BL/6J mice maintained comparable weights at the end of the 14-day course, with baseline weight of 29.8 0.7 grams compared to post-vehicle control weight of 29.4 0.8 grams

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Historical background of RNA-based therapeutics Significant advancements in gene sequencing technology have been made after the completion of the human genome project in 2003, which deepened our understanding of genetic causes for different diseases (Goodwin et al., 2016) and paved the way for the development of RNA-based therapeutics, which target disease-related genes that could not be targeted by conventional drugs, small molecules or protein-based drugs (Kaczmarek et al., 2017)

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