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However, lifestyle interventions are notoriously difficult to maintain [135], suggesting that some patients may benefit from pharmacological therapy

Together, these data indicate that FAO reprogramming in lung-associated macrophages occurs via a DUSP5-mediated mechanism in response to BCG infection and offers both DUSP5 modulation, and FAO inhibition, as potential therapeutic avenues to modify the severity of sequelae associated with Mtb infection

In addition to the HSC changes mentioned above, aging marrow also has decreased Wnt signaling and the accumulation of senescent cells and inflammatory cytokines

doi: 10.3233/CH-162042