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Evidence showed, as mentioned, wide therapy counteracting potential (NO-release, NO-synthase (NOS)-inhibition (L-NAME), NOS-over-activity (L-arginine), NO-system immobilization (L-NAME+L-arginine)
As with current models of NMDAR function, based on crystallography, experimental, and in silico advances, investigation of this complex problem will require a macromolecular approach, involving not only the interaction between subunits, but also the interacting domains of the receptor
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