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Am J Respir Cell Mol Biol 39(3):312323 Menon B, Singh M, Ross RS, Johnson JN, Singh K (2006) beta-adrenergic receptor-stimulated apoptosis in adult cardiac myocytes involves MMP-2-mediated disruption of beta1 integrin signaling and mitochondrial pathway
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However, as discussed in the next section, key historical events affecting APAP use in the pediatric population have been documented that can be useful in estimating APAP use through time
