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Description
Small Molecule Activators of SIRT1 as Therapeutics for the Treatment of Type 2 Diabetes
[DOI] [PubMed] [Google Scholar] 29.Deth R, Muratore C, Benzecry J, Power-Charnitsky VA, Waly M
Here, we show that impaired OGDHc activity (via ABHD11 inhibition) in human CD8 + lymphocytes has distinct effects from those observed in cancer cells, with the perturbed TCA cycle driving synthesis of unsaturated fatty acids, rather than the accumulation of 2-HG that inhibits 2-OGDDs
Addressing what created it will
