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For comparisons B and C, ORA was performed using the GOBP database 92 (release 2023) and the Reactome Pathway Knowledgebase 93 (release 2022) to identify over-represented pathways in the upregulated gene sets (padj 0.05 and padj 0.01, respectively)

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By quantifying the bioavailability of tamoxifen (TAM) and its metabolites and by assessing genomic recombination using the GLAST-Cre ERT2 knockin mouse line, we provide a rationale for optimal protocols of recombination (Fig