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However, also dietary/drinking water Se excess is associated with infertility and testicular degeneration in experimental animals, related to higher GPX4 and lactate dehydrogenase activity and higher hydrogen selenide production, and reduced spermatozoa motility, concentration, and typical spermatozoa morphological defects (with the fusion of two midpieces, vacuolization of the cytoplasm, and twisted tails) (85, 105, 117, 169)

Evidence from human kidney disease In humans, tubular cell death was the best histopathological correlate of renal dysfunction in the so-called acute tubular necrosis form of AKI.81 Acute tubular necrosis (a term coined in the 19th century an unrelated to current concepts of cell death modalities) is the most common form of AKI
In one embodiment, the analog is: hexanoic-tyrosine-isoleucme-(6)-amino-hexanoic amide
