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In the context of periodontitis, the increased expression of SLC7A11 likely represents a compensatory response to elevated oxidative stress, as ferroptosis characterized by iron-dependent lipid peroxidation has been shown to be involved in inflammatory diseases including periodontitis [24]

The length of the interventions has varied from three to twelve months, as have the requirements for patient inclusion (e.g., baseline TSH cut-offs, antibody thresholds, and pregnancy status)

As discussed below, such domains will spontaneously aggregate together with similar or different proteins, increasingly destabilizing the function of such oxidatively modified proteins and eventually leading to cell death

doi: 10.1016/j.ajpath.2014.10.009 134 Veses-GarciaM.LiuX.RigdenD