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In a classic work from Spagnoletti et al
Curcumin Curcumin, a polyphenolic compound derived from turmeric, is widely studied for its antioxidant and anti-inflammatory properties

This includes loss of skeletal mass in addition to improved appetite (4)

An open-label trial used VEGF165 gene transfer as an intra-muscular injection in the ischemic thigh in patients with critical ischemia with/without DM