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Description
These effects of GCs manifest most clearly in patients with Cushing syndrome, in whom profound increases in total and visceral adipose tissue mass is commonly observed 1,19,4249 while increases in the subcutaneous depots are moderate

Hepatocyte-specific Gclc deletion leads to rapid onset of steatosis with mitochondrial injury and liver failure
The administration fee alone rarely covers the full cost of clinical time, which is why most practices rely on the drug margin (the difference between acquisition cost and reimbursement) for profitability in buy-and-bill arrangements

Neurobiological and behavioral mechanisms of circadian rhythm disruption in bipolar disorder: a critical multi-disciplinary literature review and agenda for future research from the ISBD task force on chronobiology