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[57] High serum levels may caused by supplementing with vitamin B 12 , present of antibodies to intrinsic factor, or due to underlying condition

When critically ill patients progress to AKI stage 3, a suitable combination of CRRT and nutritional supplementation should be considered as AKI is accompanied by metabolic and physiological disturbances and CRRT leads to the loss of micronutrients and macronutrients

This suggests that the quinone head group is a structural requirement for the anti-ferroptotic function

Furthermore, intradermally administered nanoparticles interact intimately with dermal immune cells, such as dendritic cells and macrophages, thereby modulating local immune responses and reducing systemic exposure, which enhances therapeutic efficacy, biocompatibility, and patient safety