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Studies over the last two decades have shown that physiological and metabolic abnormalities, such as immune dysregulation/neuro-inflammation, redox imbalance/oxidative stress, mitochondrial dysfunction, environmental toxicant exposures and gut dysbiosis, can all be important aspects of the pathophysiology of ASD [164]

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Figure 6 The effects of GGC in human astrocytes is relevant for neuroprotection in AD and other neurodegenerative diseases since astrocytes represent the supporting cells in the brain and protect neurons against oxidative stress and enhance neuronal survival during cytotoxic conditions

Although a fairly large proportion of patients have reported a number of side effects, particularly at the gastrointestinal level (nausea, vomiting, diarrhoea), these side effects tend to diminish over time and adherence to treatment remains high, with about 5% of patients discontinuing treatment due to side effects