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ROS are necessary for certain cellular functions, such as mitochondrial or endothelial functions, normally in low and stable levels

NK cell cytotoxicity (a marker of immune function) was enhanced more than two-fold in the high-dose group after three months

Biochem Biophys Res Commun 205(2):10641071 Cederbaum AI et al (2012) CYP2E1 sensitizes the liver to LPS- and TNF -induced toxicity via elevated oxidative and nitrosative stress and activation of ASK-1 and JNK mitogen-activated kinases