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Some methodological details are so fundamental (e.g., brainstem registration, or selection of a baseline reference brain region or metabolite, or choosing between blood serum and cerebrospinal fluid) that they can be completely responsible for a study's results or lack thereof

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Other studies have shown that ROS production in response to glutamine deprivation increases the expression of p53-dependent genes ( Gadd45a, Cdkn1, and Sestrin2 ) via B55 or IKK 124,125