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R., Giorgi, C., Lebiedzinska, M., Duszynski, J

Clin Chem 44 : 825832 Robinson BH, Glerum DM, Chow W, Petrova-Benedict R, Lightowlers R, Capaldi R 1990 The use of skin fibroblast cultures in the detection of respiratory chain defects in patients with lacticacidemia

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[7] [8] NAD+ and NADH are continuously recycled during redox reactions, but during other metabolic activities, they are absorbed by NAD+-dependent enzymes and may subsequently become depleted over time, increasing the risk of DNA damage, age-related illnesses, and mitochondrial malfunction