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The most severe conditions associated with defects in the axis may cause a loss of adult height of approximately 1/3 and may cause severe developmental and neurological deficits and compromise pubertal maturation and fertility

FerroOrange intensity was measured at excitation and emission wavelengths of 543 and 580 nm, respectively, using an EnSpire Multi Plate Reader (PerkinElmer, MA, USA)

These organisms are also capable of converting (3 R ,3 R )-zeaxanthin to (3 S ,3 S )-AX, which has the same optical configuration due to pre-existing C3 and C3 hydroxylation (Supplementary Figure S4) [290]

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