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A glitch in the matrix: organ-specific matrisomes in metastatic niches
Complications seen with diabetes range from heart disease (2 to 4 times higher occurence than in non-diabetics) to blindness, kidney disease, amputations, nerve damage and erectile dysfunction
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Therefore, pharmacological agents that mimic or enhance irisin signalingsuch as stable irisin analogs or small-molecule agonistsmay offer a viable alternative for maintaining therapeutic levels without relying solely on physical exercise
