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Iron chelation and regulation of the cell cycle: 2 mechanisms of posttranscriptional regulation of the universal cyclin-dependent kinase inhibitor p21CIP1/WAF1 by iron depletion

In contrast, mitochondrial energy stress may suppress ferroptosis through AMPK-mediated acetyl-CoA carboxylase alpha (ACACA) phosphorylation
doi: 10.1016/j.cell.2015.07.017

Recent research highlights that inhibition of its rate-limiting enzyme, AR, may substantially mitigate vascular dysfunction and related complications in DM [19, 147]
